Selected Scientific Publications

cDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV.
Hajjou M, Norel R, Carver R, Marion P, Cullen J. Rogler LE, Rogler CE. J Med Virol 77: 57-65 (2005).

In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.
Bordier BB, Ohkanda J, Liu P, Lee SY, Salazar FH, Marion PL, Ohashi K, Meuse L, Kay MA, Casey JL, Sebti SM, Hamilton AD, Glenn JS. J Clin Invest. 112(3):407-14 (2003).

Entecavir therapy combined with DNA vaccination for persistent duck hepatitis B virus infection.
Foster WK, Miller DS, Marion PL, Colonno RJ, Kotlarski I, Jilbert AR. Antimicrob Agents Chemother. 47(8):2624-35 (2003).

Inhibition of hepatitis B virus in mice by RNA interference.
McCaffrey AP, Nakai H, Pandey K, Huang Z, Salazar FH, Xu H, Wieland SF, Marion PL, Kay MA. Nature Biotechnol. 21(6):639-44 (2003).

A transgenic mouse lineage useful for testing antivirals targeting hepatitis B virus.
Marion PL, Salazar FH, Liittschwager K, Bordier BB, Seeger C, Winters MA, Cooper AD and Cullen JM. In Frontiers in Viral Hepatitis, Schinazi, RF, ed.; Elsevier Science NL, pp 197-209, (2003).

A prenylation inhibitor prevents production of infectious hepatitis delta virus particles.
Bordier BB, Marion PL, Ohashi K, Kay MA, Greenberg HB, Casey JL, Glenn JS. J Virol. 76(20):10465-10472 (2002).

Potent efficacy of entecavir (BMS-200475) in a duck model of hepatitis B virus replication.
Marion PL, Salazar FH, Winters MA, Colonno RJ. Antimicrob Agents Chemother. 46(1):82-88 (2002).

Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses.
Ohashi K, Marion PL, Nakai H, Meuse L, Cullen JM, Bordier BB, Schwall R, Greenberg HB, Glenn JS, Kay MA. Nat Med. 6(3):327-331 (2000).

Absence of mutations in the p53 tumor suppressor gene in woodchuck hepatocellular carcinomas associated with hepadnavirus infection and intake of aflatoxin B1.
Rivkina M, Cote PJ, Robinson WS, Tennant BC, Marion PL. Carcinogenesis 17(12):2689-2694 (1996).

Amino acids essential for RNase H activity of hepadnaviruses are also required for efficient elongation of minus-strand viral DNA.
Chen Y, Marion PL. J Virol. 70(9):6151-6156 (1996).

Non-neoplastic liver disease associated with chronic ground squirrel hepatitis virus infection.
Cullen JM, Marion PL. Hepatology. 23(6):1324-1329 (1996).

State of the p53 gene in hepatocellular carcinomas of ground squirrels and woodchucks with past and ongoing infection with hepadnaviruses.
Rivkina MB, Cullen JM, Robinson WS, Marion PL. Cancer Res. 54(20):5430-5437 (1994).

Selected mutations of the duck hepatitis B virus P gene RNase H domain affect both RNA packaging and priming of minus-strand DNA synthesis.
Chen Y, Robinson WS, Marion PL. J Virol. 68(8):5232-5238 (1994).